11C Methane Target


Target system for easy and reliable production of high activities of in target produced [11C]CH4, the direct precursor for high specific activity of [11C]CH3I produced in a gas phase [11C]-Methyl Iodide system. As a target gas a mixture of Nitrogen/Hydrogen (95%/5%) is used. This target generates the highest specific activities for [11C]-Methane and therefore the highest specific activities for [11C]-Methyl Iodide when using the MeI system.

Cooling systems, automated filling system as well as the adaptation for different cyclotrons are available from Synthra. Nuclear reaction 14N(p,α)11C. Target volume about 70 ml. Conical target body. Filling pressure 15 bar. Yield about 111 GBq (3 Ci) in 30min with a 40µA current and 15 MeV (degraded) beam.



H2O Titanium Target


Used for production of highly reactive 18F fluoride from H218O. The heart of the target is a titanium cavity for the O-18 water. No other materials are in contact with the O-18 water during bombardment. Due to the highly inert material, no cleaning procedures after or before bombardments are necessary. The high pressure target is water cooled from the back and helium cooled from the front. This ensures the high yield, as the beam is fully stopped in the O-18 water. As titanium is a highly inert material, this target cavity is the gold standard in producing highly reactive 18F for nucleophilic substitution reactions. Production yields are 93 GBq (2.5 Ci) for a 16 MeV proton beam of 35 µA for 60 minutes. FDG yields and especially more sophisticated nucleophilic substitution reaction yields are significantly higher when using this target cavity.

Cooling systems, automated filling system as well as the adaptation for different cyclotrons are available from Synthra. Nuclear reaction 18O(p,n)18F. Target volume about 1 ml. Yield about 90 GBq (2.4 Ci) in 1 hour with a 36µA 16 MeV beam current.



H2O Tantalum Target


Used for production of highly reactive 18F fluoride from H218O. The heart of the target is a tantalum cavity for the O-18 water. No sputtering or erosion like in commonly used silver targets occurs. Due to the highly inert material, no cleaning procedures after or before bombardments are necessary. As an additional advantage the tantalum target cavity activates very low. The high pressure target is water cooled from the back and helium cooled from the front. This ensures the high yield, as the beam is fully stopped in the O-18 water. Cooling systems, automated filling system as well as the adaptation for different cyclotrons are available from Synthra. Target maintenance of this highly advanced target cavity is reduced to the stability of the used front foil. Foil change after 5 000-to 10 000 µAh is the only maintenance to be done when using this target cavity in an 18F production environment. Production yields are 90 GBq (2.4Ci) for a 16 MeV proton beam of 35 µA for 60 minutes. FDG yields are significantly higher when using this target cavity.


[18F]F2 Gas Target


A highly sophisticated target for high F2 yields adapted for the GE PET Trace cyclotron. Adaptation for different cyclotrons are available from Synthra. The inner target wall is coated with a 100 µm Gold layer of 99.995% purity. All metal parts are laser welded and all sealings are metal sealings, either silver or gold. The front window is helium cooled and made out of 50µm havar foil. The target is specified for up to 40µA current for high yield fluorine productions. Target cooling is performed by a water cooling jacket. Operation of the target is performed by a Synthra target control software with commands for evacuating the target, filling the target, recovering the O-18 Oxygen to the cryo trap command, a filling with Helium/F2 command for the second bombardment and an emptying command.

Nuclear reaction 18O(p,n)18F. Target volume about 70 ml. Yield about 45 GBq (1.2 Ci) after 1 hour bombardment with a 40µA 16 MeV beam current and after second bombardment for 20 min using F2/ He/Ar mixture.